The Importance of Quality HER2 Testing for Breast Cancer

Video Overview

HER2 testing can be impacted by many factors, including tissue acquisition, time to and duration of fixation, artifacts, specimen interpretation by IHC and FISH, and tumor heterogeneity.

Quality in HER2 testing is critical for treatment decisions.

CHAPTER 1: THE BASICS OF HER2

Overview of the HER2 protein found on the surface of cells and HER2 overexpression.

When a patient is HER2+, HER2 protein is overexpressed on the cell surface.

CHAPTER 2: FOLLOW THE SAMPLE

Review of key HER2 testing processes based on ASCO/CAP consensus guidelines.

CHAPTER 3: MOST COMMONLY USED TESTING METHODS

Overview of IHC and FISH testing for breast cancer.

CHAPTER 4: WHAT CAN GO WRONG WITH TESTING?

Review of potential factors (overfixation, underfixation, artifacts, and tumor heterogeneity) that may impact quality in HER2 testing.

CHAPTER 5: WHAT CAN BE DONE TO ENSURE ACCURACY?

Summary of key steps that may help ensure quality in HER2 testing.

The interpretation and scoring of the tissue samples depicted in this video are for illustration purposes only and do not replace a physician’s medical training, judgment, and experience in this matter.